Composite & Smart Collagen Biomaterials for Multi‑Tissue Regeneration: Drug Delivery and Bioactive Composites
Drug Delivery
DOI:
https://doi.org/10.22034/LSSJ.2026.188Keywords:
collagen, periodontal regeneration, guided tissue regeneration, dental biomaterials, alveolar bone, membranes.Abstract
Background: Collagen, the most abundant protein in the extracellular matrix (ECM), provides an ideal platform for designing composite and “smart” biomaterials that simultaneously deliver therapeutic agents and guide tissue regeneration.
Aim: This review critically examines the state of the art in collagenbased composite scaffolds, hydrogels, nanoparticles, and 3Dprinted constructs that incorporate bioceramics, synthetic polymers, growth factors, and stimuliresponsive elements.
Result: Emphasis is placed on materials that exhibit bioactivity, controlled drug/growthfactor release, and environmental responsiveness for the repair of bone, cartilage, skin, and vascular tissues. Recent advances in recombinant collagen, macromolecularcrowdingbased assembly, and mesoscale mineralization are highlighted.
Discussion: The review concludes with a discussion of current challenges and future directions, including 4D bioprinting and artificialintelligencedriven material design.
Keywords: Smart Collagen Biomaterials, Tissue Regeneration, Drug Delivery,Bioactive Composites
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